Recrystallize the maleic anhydride from toluene. Maleic anhydride in daily doses of 20, 40,100, 250 or 600 mg/kg body weight, fed for 90 days to groups of 15 rats of each sex, caused macroscopic changes in the kidneys: enlargement and pale yellow discoloration. 5. Rinse mouth with water (only if the person is conscious). First Aid Measures Description of Firstaid Measures General Advice: Consult a physician. Remove victim to fresh First-aid measures General Advice Show this safety data sheet to the doctor in attendance. Moisture sensitive. Causes redness and MALEIC ACID page 2 of 6 This Fact Sheet is a summary source of information of all ... (as Maleic Anhydride) exists, use a MSHA/NIOSH approved self-contained breathing apparatus with a full facepiece operated in a … Chem., 1979, 179, C19], and is considered an excellent dieneophile for Diels-Alder reactions [Felthouse, Timothy R. et al. Causes chemical burns to the respiratory tract. Stir the mixture for 10 min. (5,8) The vapor pressure for maleic anhydride is 0.1 to 0.2 mm Hg at 25 °C. Causes redness and pain. Strong oxidizers, water, alkalis, metals, caustics & amines above 150°F Since it biodegrades in sewage treatment plants and hydrolyzes, it's likely that it will degrade in soil. Acute (short-term) inhalation exposure of humans to maleic anhydride has been observed to cause irritation of the respiratory tract and eye irritation. Hazard classification & labelling Hazard classification and labelling. Causes respiratory Product Safety Assessment: Maleic Anhydride Last Revised: August 2015 Page 2 of 3 Potential Human Health Effects Occupational Exposure Potential for occupational exposure to Maleic Anhydride exists during manufacture, at transloading, storage and staging areas, and during mixing and sampling operations in the manufacture of other products. EC -No. (2) Maleic anhydride has an acrid odor, with an odor threshold of 0.32 parts per million (ppm). 6. Harmful if swallowed. : 108-31-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratorychemicals, Industrial & for professional use only. +86-532-8027466 SECTION 1: PRODUCT AND COMPANY IDENTIFICATION ... Acrylic acid maleic anhydride copolymer, aka: 2-propenoic acid, polymer with 2,5, furandion e (cis-butenedioic anhydride) 52255-49-9 : ... Acrylic Acid Maleic … Dissolve the residue in a minimal amount of chloroform. Potential Health Effects Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Causes eye burns. SAFETY DATA SHEET (in accordance with Regulation (EU) 2015/830) 108120-Maleic anhydride Version: 3 Revision date: 19/04/2016 Page 2 of 9 Print date: 19/04/2016 -Continued on next page.- P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. 1272/2008, Regulation (EC) No.1907/2006 Maleic Anhydride, rev 2 7/2012 Page 2 Basis for Classification This substance is classified based on Directive 1272/2008/EC and its amendments (CLP Regulation,GHS) MALEIC ANHYDRIDE (108-31-6) Maleic acid 110-16-7 >95 4. Exposure to maleic anhydride may occur from accidental releases to the environment or in workplaces where it is produced or used. Maleic anhydride is used in the formulation of resins. Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. reaction, which becomes evident upon re-exposure to this material. Evaporate the chloroform in a hood. National Cancer Institute, June 17, 1974. Anhydrides. 1.3 Details of the supplier of the safety data sheet Company : Central Drug House (P) Ltd 7/28 Vardaan House New Delhi-10002 INDIA respiratory tract. Since it biodegrades in sewage treatment plants and hydrolyzes, it's likely that it will degrade in soil. Wash out mouth with water. Maleic anhydride undergoes a potentially explosive exothermic Diels-Alder reaction with 1-methylsilacyclopenta-2,4-diene at 150C [Barton, T. J., J. Organomet. The anhydride of maleic acid has five atoms in its cyclic molecule, the unsaturated bond undergoes free radical polymerization in the presence of an initiator. NCI [1974]. Maleic anhydride, polymers Safety Profile. If not breathing, give artificial respiration. FIRST AID MEASURES General advice Consult a physician. Danger! Ingestion: Exposure to high fume concentrations cause photophobia, Since it biodegrades in sewage treatment plants and hydrolyzes, it's likely that it will degrade in soil. Eye: Causes severe eye and skin irritation with possible Substance Any concentration shown as a range is to protect confidentiality or is due to batch variation. A poison by intravenous route. MCA [1974]. Maleic Anhydride 95 - 100% 108-31-6 Get medical attention immediately. Chemical name :maleic anhydride Substance/mixture : Occupational exposure limits, if available, are listed in Section 8. Prolonged or repeated skin contact may cause dermatitis. Inhalation: Saving Lives, Protecting People, The National Institute for Occupational Safety and Health (NIOSH), National Institute for Occupational Safety and Health, A – NIOSH Potential Occupational Carcinogens, E – OSHA Respirator Requirements for Selected Chemicals, G – 1989 Air Contaminants Update Project: Exposure Limits NOT in Effect, Type C & CE – Definitions for Type C and Type CE Respirators, U.S. Department of Health & Human Services. The odour warning when the exposure limit value is exceeded is insufficient. tract irritation and possible burns. Pesticide properties for Maleic hydrazide, including approvals, environmental fate, eco-toxicity and human health issues Product name : Maleic anhydride Product Number : 63200 Brand : Sigma-Aldrich Index-No. Add 0.98 g (0.01 mole) of maleic anhydride to a solution of 1.67 g (0.01 mole) of veratrylamine in 10 mL of chloroform. Move out of dangerous area. Maleic anhydride is a colorless to white solid that forms orthorhombic crystals and decomposes in water. Safety Data Sheet 24 hour Emergency Response No. Wear safety goggles or eye protection in combination with breathing protection if powder. 108 -31 -6 203 -571 -6 607 -096 -00 -9 - 4. May cause asthmatic attacks due to allergic sensitization of the Show this safety data sheet to the doctor in attendance.Move out of dangerous area. Corrosive. "Maleic Anhydride, Maleic Acid, and Fumaric Acid." Show this safety data sheet to the doctor in attendance. Harmful if swallowed. Immediate medical attention is required. Repeated Colorless needles, white lumps, or pellets with an irritating, choking odor. If inhaled If breathed in, move person into fresh air. ... Maleic anhydride is transported also as hot liquid (70°C); contact of the skin should be avoided. Environmental: Maleic anhydride's fate in soil is unknown. Common Name Maleic Anhydride Synonym(s) 2,5Furandione Formula C 4 H 2 O 3 CAS Number 108316 COMPONENT CAS NUMBER CONCENTRATION Maleic Anhydride 108316 ≤ Section 4. Washington, DC: Manufacturing Chemists Association, p. 1-13. P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER/doctor. Reproductive Toxicity: No data available Reproductive toxicity - Rat - Oral Environmental: Maleic anhydride's fate in soil is unknown. CDC twenty four seven. Memorandum. Up to 10 mg/m3: (APF = 25) Any supplied-air respirator operated in a continuous-flow mode£(APF = 50) Any self-contained breathing apparatus with a full facepiece(APF = 50) Any supplied-air respirator with a full facepiece, Emergency or planned entry into unknown concentrations or IDLH conditions: (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus, Escape: (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister having an N100, R100, or P100 filter. 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